Understanding how intestinal stem cells heal inflammation in bowel disease
Official title: Intestinal Stem Cell Metabolism in Inflammatory Bowel Disease Mucosal Healing
Funded at University of Pittsburgh at Pittsburgh · NIH-10932840 · Data updated 2026-11-12
This study is looking at how certain stem cells in the gut help heal inflammation from conditions like Crohn's disease and ulcerative colitis, using a special 3D model to understand how these cells work during the healing process, which could lead to better treatments for IBD.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | August 10, 2023 |
| Project end | August 9, 2026 |
| Funding year | 2024 |
| Award (this year) | $91,432 |
| NIH project number | 5F32DK132826-02 |
| Project ID | NIH-10932840 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease, including Crohn's disease and ulcerative colitis.
✕Less likely to help
Patients with other gastrointestinal disorders unrelated to inflammatory bowel disease may not benefit from this research.
What this research studies
This research investigates the role of intestinal stem cells in healing the inflammation caused by inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis. By using a specialized 3D organoid model, researchers aim to explore how the metabolism of these stem cells affects their ability to repair damaged intestinal tissue. The study focuses on identifying specific populations of stem cells that are activated during inflammation and how they contribute to the healing process. This approach may lead to new insights that enhance current treatments for IBD.
Why it matters
Potential benefit: If successful, this research could lead to improved healing strategies for patients suffering from inflammatory bowel disease.
How similar studies have gone: Previous research has shown promise in understanding stem cell roles in tissue repair, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Mentrup, Heather — University of Pittsburgh at Pittsburgh
- Study coordinator: Mentrup, Heather
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.