Understanding how intestinal lymphatic vessels function and what causes their dysfunction
Official title: Morphogenetic mechanisms of intestinal lymphatic smooth muscle-lacteal complex function and dysfunction
Funded at Cornell University · NIH-11170192 · Data updated 2026-11-12
This study is looking at how certain vessels in the intestines work to absorb fats and what happens when they don't function properly, focusing on a specific factor that helps them develop; the goal is to find out how this relates to conditions like fatty liver disease, which could lead to new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $643,700 |
| NIH project number | 1R56DK139238-01 |
| Project ID | NIH-11170192 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals over 21 years old who may be experiencing issues related to fat absorption or liver disorders.
✕Less likely to help
Patients with conditions unrelated to intestinal lymphatic function or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the mechanisms behind the function and dysfunction of lymphatic vessels in the intestines, which are crucial for absorbing dietary fats. The study focuses on a specific transcription factor, Pitx2, that influences the development of these vessels and their smooth muscle components. By examining how these structures form and repair themselves, the research aims to uncover the links between their dysfunction and conditions like fatty liver disease. Patients may benefit from insights that could lead to new treatments for related disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for conditions related to fat absorption and liver health.
How similar studies have gone: While the specific mechanisms being studied may be novel, there is existing research indicating that understanding lymphatic function can lead to significant advancements in treating related health issues.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Kurpios, Natasza a — Cornell University
- Study coordinator: Kurpios, Natasza a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.