Understanding how intestinal fungi grow in patients with weakened immune systems
Official title: Unraveling the ecology of intestinal fungal expansion in immunocompromised patients through computational modeling and machine learning
Funded at Sloan-Kettering Inst Can Research · NIH-11094012 · Data updated 2026-11-12
This study is looking at how certain fungi grow in the guts of patients with weakened immune systems, especially those who have had a specific type of stem cell transplant, to help doctors understand how this affects their health and improve their treatment.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 23, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $122,048 |
| NIH project number | 5K99AI175599-02 |
| Project ID | NIH-11094012 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are immunocompromised patients, especially those who have received allogeneic hematopoietic cell transplants.
✕Less likely to help
Patients who are not immunocompromised or those who have not undergone allogeneic hematopoietic cell transplantation may not benefit from this research.
What this research studies
This research investigates the growth of intestinal fungi in immunocompromised patients, particularly those who have undergone allogeneic hematopoietic cell transplantation. By utilizing advanced computational modeling and machine learning techniques, the study aims to analyze microbiome data collected from hospitalized patients. The goal is to uncover the relationships between fungal expansion and clinical outcomes, ultimately improving patient care and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to better management and treatment options for infections in immunocompromised patients.
How similar studies have gone: Previous research has shown promising results in understanding microbial communities in similar patient populations, indicating that this approach has potential for success.
Where this research is happening
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Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Liao, Chen — Sloan-Kettering Inst Can Research
- Study coordinator: Liao, Chen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.