Understanding how intestinal cells sort proteins for nutrient absorption
Official title: Developmental regulation of epithelial polarization by pre-mRNA splicing
Funded at Duke University · NIH-10983745 · Data updated 2026-11-12
This study is looking at how tiny cells in the gut help move important proteins to the right spots so our bodies can absorb nutrients better, using zebrafish to learn more about the genes and processes involved, which could help us understand gut health and diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | February 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $419,543 |
| NIH project number | 5R01DK132120-03 |
| Project ID | NIH-10983745 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with gastrointestinal disorders affecting nutrient absorption.
✕Less likely to help
Patients with non-intestinal related health issues or those without absorption disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms by which intestinal epithelial cells sort proteins to their apical membrane, which is essential for nutrient absorption. Using zebrafish as a model organism, the study explores genetic factors and cellular processes that influence this sorting during development. The researchers focus on the role of pre-mRNA splicing in regulating these pathways, aiming to uncover how these processes contribute to the proper functioning of the intestinal epithelium. By understanding these mechanisms, the research seeks to provide insights into intestinal health and disease.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to nutrient absorption and intestinal disorders.
How similar studies have gone: Previous research has shown success in understanding cellular mechanisms in other contexts, suggesting potential for breakthroughs in this area as well.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Bagnat, Michel — Duke University
- Study coordinator: Bagnat, Michel
Related research
Other NIH-funded projects on the same topics.
-
Investigating genetic factors in Lewy body diseases
This study is looking at how changes in a specific gene might play a role in conditions like Parkinson's disease and dementia, so that people can better understand how their genetics affect their health and possibly find more tailored treatments.
-
Targeting the PAX3-FOXO1 protein in a deadly childhood cancer
This study is looking at a specific protein that helps a tough childhood cancer called alveolar rhabdomyosarcoma, with the goal of finding new ways to treat kids who have this illness.
-
Improving population health by studying reproduction and development
This study is looking at how different things in our environment can impact pregnancy and the health of babies, and it’s for people who are planning to have children or are already parents, as it aims to help improve understanding and outcomes for everyone involved.
-
Modeling axon degeneration in C. elegans to help ALS patients
Researchers are using a tiny worm model to uncover how axons break down, which could point to new ways to help people with ALS and related nerve diseases.
-
Induced Suppression of Platelet Activity in Aneurysmal SAH Management
A new approach tests whether carefully reducing platelet activity can improve outcomes after aneurysmal subarachnoid hemorrhage.
-
AI-enhanced virtual reality tool to support remote emergency brain surgery training in Tanzania
A new AI-powered virtual reality tool helps non-experts in low-resource areas get real-time remote guidance for emergency traumatic brain injury surgery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.