Understanding how intestinal cells sort proteins for nutrient absorption
Developmental regulation of epithelial polarization by pre-mRNA splicing
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-10983745
This study is looking at how tiny cells in the gut help move important proteins to the right spots so our bodies can absorb nutrients better, using zebrafish to learn more about the genes and processes involved, which could help us understand gut health and diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10983745 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which intestinal epithelial cells sort proteins to their apical membrane, which is essential for nutrient absorption. Using zebrafish as a model organism, the study explores genetic factors and cellular processes that influence this sorting during development. The researchers focus on the role of pre-mRNA splicing in regulating these pathways, aiming to uncover how these processes contribute to the proper functioning of the intestinal epithelium. By understanding these mechanisms, the research seeks to provide insights into intestinal health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with gastrointestinal disorders affecting nutrient absorption.
Not a fit: Patients with non-intestinal related health issues or those without absorption disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions related to nutrient absorption and intestinal disorders.
How similar studies have performed: Previous research has shown success in understanding cellular mechanisms in other contexts, suggesting potential for breakthroughs in this area as well.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAGNAT, MICHEL — DUKE UNIVERSITY
- Study coordinator: BAGNAT, MICHEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.