Understanding how intestinal cells respond to Toxoplasma gondii infection
Mucosal immunity to Toxoplasma gondii
This study is looking at how certain cells in your gut help your body fight off Toxoplasma gondii, a common germ that can come from food, and it aims to understand how these cells react during infection, which could help us learn more about keeping your gut healthy while battling this germ.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10877495 on NIH RePORTER |
What this research studies
This research investigates the immune response to Toxoplasma gondii, a common foodborne pathogen, focusing on the role of intestinal epithelial cells (IECs) in mediating immune responses. It aims to uncover how these cells respond to the cytokine IFN-γ during infection, which is crucial for host defense. The study will explore both protective and harmful immune responses, particularly how IECs contribute to tissue damage while fighting the infection. By identifying specific IEC responses and metabolic changes during infection, the research seeks to provide insights into the mechanisms of mucosal immunity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with Toxoplasma gondii infection or are at high risk of exposure to this pathogen.
Not a fit: Patients who do not have Toxoplasma gondii infection or are not at risk of exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of infections caused by Toxoplasma gondii, potentially enhancing patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding immune responses to similar pathogens, suggesting that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Yarovinsky, Felix — University of Rochester
- Study coordinator: Yarovinsky, Felix
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.