Understanding how intervertebral discs heal and regenerate
Mechanisms for Regenerative Healing in Intervertebral Discs
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11007273
This study is looking at how the discs in our spines heal after injury, especially to help people with back pain, by testing different ways to encourage healing in young and older mice.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11007273 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind healing in intervertebral discs, which are crucial for spinal health and often contribute to back pain when they degenerate. The team is developing a model to study how different cell populations in the discs respond to injury and how factors like tissue stiffness affect healing. By comparing healing processes in young and mature mice, the researchers aim to identify effective strategies for repairing damaged discs in humans. This could lead to improved treatments for patients suffering from back pain due to disc degeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing back pain related to intervertebral disc degeneration.
Not a fit: Patients with back pain not related to intervertebral disc issues or those who are not adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively repair intervertebral discs, reducing back pain and improving quality of life for patients.
How similar studies have performed: Previous research has shown promise in regenerative therapies for intervertebral discs, but this approach aims to optimize healing strategies based on natural processes, making it a novel investigation.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: IATRIDIS, JAMES C. — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: IATRIDIS, JAMES C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.