Understanding how intervertebral discs can heal and regenerate
Mechanisms for Regenerative Healing in Intervertebral Discs
This study looks at how intervertebral discs heal after injury, focusing on the differences between young and adult mice, to find ways to improve healing and create better treatments for people with back pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11246138 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind healing in intervertebral discs, which are often damaged and contribute to back pain. By studying the differences in healing between young and adult mice, the research aims to identify cellular and mechanical factors that influence successful regeneration. The approach includes developing a model to better understand how these discs can be repaired and what strategies might enhance healing in humans. The ultimate goal is to inform new treatments that could improve recovery from disc-related injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults suffering from intervertebral disc degeneration or related back pain.
Not a fit: Patients with acute back injuries or those who do not have intervertebral disc degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance the healing of intervertebral discs, reducing back pain and improving quality of life for patients.
How similar studies have performed: Previous studies have shown promise in regenerative therapies for intervertebral discs, but this research aims to explore novel approaches that have not yet been fully tested.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Iatridis, James C. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Iatridis, James C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.