Understanding how intervertebral disc degeneration affects pain signals in the nervous system
Intervertebral Disc Degeneration and Cross-Talk with the Nervous System - NOSI Diversity Supplement
This study is looking at how worn-out discs in the spine might cause back pain by examining how they interact with nerves, and it's also helping train new scientists in the field of biomedical engineering.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11036143 on NIH RePORTER |
What this research studies
This research investigates the relationship between intervertebral disc degeneration and pain generation by studying changes in nerve function in a mouse model. The project aims to explore how the degenerating discs communicate with the nervous system, which could provide insights into the mechanisms of low back pain. Additionally, the research includes training for new scientists and organizing a conference to support academic careers in biomedical engineering. The approach combines in vitro techniques with advanced modeling to enhance understanding of this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing low back pain potentially related to intervertebral disc degeneration.
Not a fit: Patients with low back pain not associated with intervertebral disc degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for low back pain associated with intervertebral disc degeneration.
How similar studies have performed: Previous research has shown promising results in understanding pain mechanisms related to intervertebral disc degeneration, indicating that this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Setton, Lori a. — Washington University
- Study coordinator: Setton, Lori a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.