Understanding how internal brain states affect decision-making in rodents
Official title: P3: Internal Brain States
Funded at Princeton University · NIH-10900685 · Data updated 2026-11-12
This study looks at how different brain conditions affect how mice make choices, helping scientists understand the brain's role in decision-making.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Princeton University NIH-funded |
| Lab location | 1 site (Princeton, UNITED STATES) |
| Project start | August 8, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $348,364 |
| NIH project number | 5U19NS132720-02 |
| Project ID | NIH-10900685 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cognitive impairments or disorders that affect decision-making.
✕Less likely to help
Patients without cognitive impairments or those not experiencing decision-making difficulties may not benefit from this research.
What this research studies
This research investigates how different internal brain states influence decision-making strategies in rodents. By observing the behavior of mice during sensory decision-making tasks, researchers have developed a statistical model to identify these internal states. The study aims to explore the neural mechanisms behind these states using advanced techniques like large-scale neural recordings and optogenetic inactivation. This approach will help uncover how various brain regions contribute to decision-making under different conditions.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of decision-making processes, potentially informing treatments for cognitive disorders.
How similar studies have gone: Other research has shown promising results in understanding decision-making processes through similar approaches, indicating a potential for significant advancements.
Where this research is happening
-
Princeton University
Princeton, United States Active
Researchers
- Principal investigator: Pillow, Jonathan William — Princeton University
- Study coordinator: Pillow, Jonathan William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.