Understanding how interleukin 33 contributes to cancer development in chronic inflammation
Official title: Interleukin 33 Regulation for Cancer Prevention in Chronic Inflammation
Funded at Massachusetts General Hospital · NIH-11062531 · Data updated 2026-11-12
This study is looking at how a substance called IL-33, which is linked to long-term inflammation from conditions like skin or liver issues, might play a role in causing cancer, and it aims to find ways to block IL-33 to help prevent cancer in people with these chronic conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $604,063 |
| NIH project number | 5R01CA283214-02 |
| Project ID | NIH-11062531 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic inflammatory conditions such as dermatitis, pancreatitis, colitis, or hepatitis.
✕Less likely to help
Patients without chronic inflammatory diseases or those who do not have a history of cancer risk factors may not benefit from this research.
What this research studies
This research investigates the role of interleukin 33 (IL-33) in the development of cancer due to chronic inflammation. Chronic inflammatory diseases, such as dermatitis and hepatitis, can increase cancer risk, and IL-33 is identified as a key factor in this process. The study aims to uncover how IL-33 is induced in tissues under inflammatory conditions and to develop new therapies that inhibit IL-33 to prevent cancer. By focusing on the mechanisms that lead to cancer-prone chronic inflammation, the research seeks to provide insights that could lead to effective cancer prevention strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent cancer in patients with chronic inflammatory diseases.
How similar studies have gone: Previous research has shown that targeting inflammatory pathways can be effective in reducing cancer risk, suggesting that this approach may yield promising results.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Demehri, Shadmehr — Massachusetts General Hospital
- Study coordinator: Demehri, Shadmehr
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.