Understanding how interleukin 33 contributes to cancer development in chronic inflammation
Interleukin 33 Regulation for Cancer Prevention in Chronic Inflammation
This study is looking at how a substance called IL-33, which is linked to long-term inflammation from conditions like skin or liver issues, might play a role in causing cancer, and it aims to find ways to block IL-33 to help prevent cancer in people with these chronic conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11062531 on NIH RePORTER |
What this research studies
This research investigates the role of interleukin 33 (IL-33) in the development of cancer due to chronic inflammation. Chronic inflammatory diseases, such as dermatitis and hepatitis, can increase cancer risk, and IL-33 is identified as a key factor in this process. The study aims to uncover how IL-33 is induced in tissues under inflammatory conditions and to develop new therapies that inhibit IL-33 to prevent cancer. By focusing on the mechanisms that lead to cancer-prone chronic inflammation, the research seeks to provide insights that could lead to effective cancer prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic inflammatory conditions such as dermatitis, pancreatitis, colitis, or hepatitis.
Not a fit: Patients without chronic inflammatory diseases or those who do not have a history of cancer risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent cancer in patients with chronic inflammatory diseases.
How similar studies have performed: Previous research has shown that targeting inflammatory pathways can be effective in reducing cancer risk, suggesting that this approach may yield promising results.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Demehri, Shadmehr — Massachusetts General Hospital
- Study coordinator: Demehri, Shadmehr
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.