Understanding how interleukin-17 affects Alzheimer's Disease
Official title: Dissecting the modulatory functions of interleukin-17 in Alzheimer's Disease
Funded at Harvard Medical School · NIH-10590495 · Data updated 2026-11-12
This study is looking at how a molecule in your immune system and your gut bacteria might affect Alzheimer's Disease, with the hope of finding new ways to help manage the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $2,359,602 |
| NIH project number | 1RF1AG080738-01 |
| Project ID | NIH-10590495 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with Alzheimer's Disease, particularly those experiencing changes in gut health.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's Disease may not benefit from this research.
What this research studies
This research investigates the role of interleukin-17, an immune system molecule, in the development and progression of Alzheimer's Disease (AD). It aims to uncover how gut bacteria influence immune cells and their interaction with the brain, potentially affecting AD symptoms. By studying these mechanisms, the research seeks to provide insights into new therapeutic approaches for AD. Patients may be involved in understanding how their immune responses and gut health relate to their condition.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or slow the progression of Alzheimer's Disease.
How similar studies have gone: Previous research has shown promising results in understanding the immune system's role in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Huh, Jun R. — Harvard Medical School
- Study coordinator: Huh, Jun R.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.