Understanding how integrins affect intestinal immunity and healing
Official title: Regulation of Intestinal Immunity and Repair by Integrins
Funded at Benaroya Research Inst at Virginia Mason · NIH-11115731 · Data updated 2026-11-12
This study is looking at how a specific protein called αvβ6 affects the immune system and healing in people with ulcerative colitis, and it involves collecting samples from patients to help find new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Benaroya Research Inst at Virginia Mason NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | June 17, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $735,511 |
| NIH project number | 5R01DK136071-02 |
| Project ID | NIH-11115731 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with ulcerative colitis, particularly those experiencing severe symptoms or complications.
✕Less likely to help
Patients with Crohn's disease or other forms of inflammatory bowel disease may not benefit from this research.
What this research studies
This research investigates the role of integrins, specifically αvβ6, in regulating intestinal immunity and repair mechanisms in patients with ulcerative colitis (UC). By studying the immune responses and the activation of key cytokines like TGF-β, the research aims to uncover the underlying mechanisms that contribute to UC. The approach includes analyzing antibody responses and gene expression changes in both animal models and human samples to identify potential therapeutic targets. Patients may be involved in providing biological samples to help understand the disease better.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the management and outcomes of ulcerative colitis.
How similar studies have gone: Previous research has shown promising results in understanding the role of integrins in intestinal diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Benaroya Research Inst at Virginia Mason
Seattle, United States Active
Researchers
- Principal investigator: Lacy-Hulbert, Adam — Benaroya Research Inst at Virginia Mason
- Study coordinator: Lacy-Hulbert, Adam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.