Understanding how insulin signaling is controlled during cell division
Spatiotemporal control of insulin signaling by mitotic regulators
This study is looking at how insulin works in the body and what happens when it doesn't work well, especially in people with type 2 diabetes, to help find new ways to improve metabolic health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10832110 on NIH RePORTER |
What this research studies
This research investigates the regulation of insulin signaling, which is crucial for maintaining metabolic health. It focuses on how insulin receptors are internalized and how this process affects signaling pathways related to metabolism and growth. By studying these mechanisms in animal models, the research aims to uncover the causes of insulin resistance, particularly in type 2 diabetes, which affects millions globally. The approach involves identifying specific regulators of insulin receptor endocytosis and understanding their roles in metabolic homeostasis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type 2 diabetes or those at risk of developing the condition.
Not a fit: Patients with type 1 diabetes or other forms of diabetes unrelated to insulin signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing type 2 diabetes by improving insulin signaling.
How similar studies have performed: Previous research has shown promising results in understanding insulin signaling pathways, making this approach both relevant and potentially impactful.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Choi, Eunhee — Columbia University Health Sciences
- Study coordinator: Choi, Eunhee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.