Understanding how insulin signaling changes in diabetes and insulin resistance
Alterations in Post-Receptor Insulin Signaling in Diabetes and Insulin Resistance
This study is looking at how diabetes affects the way insulin works in the body, aiming to find out what goes wrong in the cells so we can better understand and treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Joslin Diabetes Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10876911 on NIH RePORTER |
What this research studies
This research investigates the alterations in insulin signaling pathways that occur in diabetes and insulin resistance. By examining how insulin and IGF-1 interact with their receptors and the subsequent cellular responses, the study aims to identify critical signaling nodes that may be disrupted in these conditions. The researchers utilize advanced techniques to analyze the phosphoproteome and have developed cellular models to better understand these processes. This work could lead to new insights into how insulin action is impaired in various tissues affected by diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with adult-onset diabetes mellitus or those experiencing insulin resistance.
Not a fit: Patients with type 1 diabetes or those without any form of insulin resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diabetes and insulin resistance, enhancing patient outcomes.
How similar studies have performed: Previous research has shown success in understanding insulin signaling pathways, making this approach both relevant and promising.
Where this research is happening
Boston, United States
- Joslin Diabetes Center — Boston, United States (Active)
Researchers
- Principal investigator: Kahn, C Ronald — Joslin Diabetes Center
- Study coordinator: Kahn, C Ronald
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.