Understanding how insulin signaling affects pancreas function in type 1 diabetes
Loss of insulin signaling across functional pancreas compartments as a major pathogenic mechanism underlying diabetic exocrine pancreatopathy
This study is looking at how insulin affects the pancreas in people with type 1 diabetes, especially how problems with insulin can lead to issues with digestion, and it aims to find new ways to help improve pancreatic health for those living with diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11010833 on NIH RePORTER |
What this research studies
This research investigates the role of insulin signaling in the pancreas of patients with type 1 diabetes, particularly focusing on how the loss of this signaling leads to pancreatic dysfunction known as diabetic exocrine pancreatopathy. The study aims to explore the interactions between insulin, acinar tissues, blood vessels, and nerve inputs within the pancreas. By examining these relationships, the researchers hope to uncover the mechanisms that contribute to pancreatic dysfunction in diabetes, which could lead to new therapeutic strategies. Patients may be involved in assessments that help identify the specific changes in their pancreatic function related to their diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with type 1 diabetes who are experiencing pancreatic exocrine dysfunction.
Not a fit: Patients without type 1 diabetes or those with other forms of pancreatic disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for pancreatic dysfunction in patients with type 1 diabetes.
How similar studies have performed: Previous research has shown that understanding insulin signaling in the pancreas can lead to significant insights into diabetes management, suggesting that this approach has potential for success.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Caicedo, Alejandro — University of Miami School of Medicine
- Study coordinator: Caicedo, Alejandro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.