Understanding how injury and repair processes lead to esophageal cancer.
Official title: Pathways of Injury and Repair in Barrett's Carcinogenesis
Funded at Case Western Reserve University · NIH-10932155 · Data updated 2026-11-12
This study looks at what happens in the esophagus when it gets hurt and how that can lead to cancer, especially for people with Barrett's esophagus, to help find better ways to prevent and treat esophageal cancer.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $2,111,965 |
| NIH project number | 5P01CA269019-02 |
| Project ID | NIH-10932155 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with Barrett's esophagus or those at high risk for developing esophageal adenocarcinoma.
✕Less likely to help
Patients without Barrett's esophagus or those who do not have risk factors for esophageal cancer may not benefit from this research.
What this research studies
This research investigates the biological processes that occur in the esophagus when it is injured and how these processes can lead to cancer. It focuses on the signaling pathways activated by injury and inflammation, particularly at the squamocolumnar junction, which is a critical area for the development of Barrett's esophagus and esophageal adenocarcinoma. By using advanced mouse models, the research aims to identify key factors and mechanisms that contribute to the transformation of normal esophageal cells into cancerous ones. Patients may benefit from insights gained into the prevention and treatment of esophageal cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating esophageal cancer.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of Barrett's esophagus and its progression to cancer, indicating that this approach has potential for success.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Chak, Amitabh — Case Western Reserve University
- Study coordinator: Chak, Amitabh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.