Understanding how inhibitory signals affect brain connections
The dual roles of GABA in excitatory synaptic plasticity
['FUNDING_R21'] · UNIVERSITY OF COLORADO DENVER · NIH-10948010
This study is looking at how certain brain signals help balance other signals to keep our brains working well, especially during development, and it's for anyone interested in understanding how our brain connections affect learning and memory.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10948010 on ClinicalTrials.gov |
What this research studies
This research investigates the roles of inhibitory synapses in regulating excitatory synapses in the brain, which is crucial for maintaining proper brain function. Using advanced techniques like two-photon microscopy and optogenetics, the study aims to explore how these inhibitory signals influence the formation and elimination of excitatory synapses during brain development. By examining the communication between these synapses, the research seeks to uncover the underlying mechanisms that contribute to cognitive processes and neural circuit plasticity.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodevelopmental disorders, particularly those on the autism spectrum.
Not a fit: Patients with purely genetic disorders unrelated to synaptic function may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into brain development and potential therapeutic strategies for conditions like autism and other neurodevelopmental disorders.
How similar studies have performed: Previous research has shown promising results in understanding synaptic interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OH, WON CHAN — UNIVERSITY OF COLORADO DENVER
- Study coordinator: OH, WON CHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder