Understanding how inhibitory signaling works in the brain's hippocampus
Official title: Architecture of inhibitory G protein signaling in the hippocampus
Funded at University of Minnesota · NIH-11088851 · Data updated 2026-11-12
This study is looking at how certain brain signals work in the hippocampus, especially focusing on a type of receptor called GABAB, to understand how problems in these signals might lead to neurological disorders, using mice to see how changes affect behavior and brain function, which could help find new treatments for these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $652,025 |
| NIH project number | 5R01NS128039-03 |
| Project ID | NIH-11088851 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological disorders that may involve dysregulation of GABAB receptor signaling.
✕Less likely to help
Patients with conditions unrelated to GABAB receptor signaling or those who do not have neurological disorders may not benefit from this research.
What this research studies
This research investigates the mechanisms of inhibitory G protein signaling in the hippocampus, focusing on the role of GABAB receptors and their interactions with specific proteins. By studying how these signaling pathways are regulated, particularly through the R7 RGS protein complexes, the research aims to uncover how disruptions in these processes may contribute to neurological disorders. The approach includes genetic studies in mice to observe changes in behavior and synaptic function when these signaling pathways are altered. This could provide insights into potential therapeutic targets for conditions linked to these signaling mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurological disorders by improving our understanding of brain signaling pathways.
How similar studies have gone: Previous research has shown promising results in understanding G protein signaling pathways, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Wickman, Kevin D — University of Minnesota
- Study coordinator: Wickman, Kevin D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.