Understanding how inherited genetics influence RAS-driven cancers
Official title: Dissecting the Role of Germline Genetics in RAS-Driven Cancers
Funded at Dana-Farber Cancer Inst · NIH-11013349 · Data updated 2026-11-12
This study is looking at how inherited genes might influence the risk and treatment of certain cancers, like pancreatic and colorectal cancer, to help doctors find ways to catch these cancers earlier and improve care for patients who are at higher risk.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $163,728 |
| NIH project number | 5K99CA286805-02 |
| Project ID | NIH-11013349 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of RAS-driven cancers or those diagnosed with such cancers who may benefit from genetic insights.
✕Less likely to help
Patients with cancers not driven by the RAS oncogene family may not receive direct benefits from this research.
What this research studies
This research investigates the role of inherited genetic factors in the development and progression of cancers driven by the RAS oncogene family, such as pancreatic and colorectal cancers. By analyzing a large dataset that includes genetic, clinical, and transcriptomic information from over 35,000 individuals, the study aims to identify germline factors that may modify cancer risk and therapeutic responses. This approach seeks to enhance early detection and intervention strategies for high-risk patients, potentially leading to better outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved screening and treatment strategies for patients at high risk of RAS-driven cancers.
How similar studies have gone: Previous research has shown promise in understanding the role of germline genetics in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Collins, Ryan Lewis — Dana-Farber Cancer Inst
- Study coordinator: Collins, Ryan Lewis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.