Understanding how inherited and tumor-specific genetic changes interact in cancer
Comprehensive identification of germline-somatic interactions
This study is looking at how your inherited genes and changes in your tumor might work together to affect how cancer grows and responds to treatment, with the hope of finding ways to tailor treatments just for you based on your unique genetic makeup.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10880544 on NIH RePORTER |
What this research studies
This research investigates the interactions between inherited genetic variants and somatic mutations in tumors, which may influence cancer progression and treatment responses. By utilizing advanced computational strategies and analyzing a large dataset of nearly 45,000 tumor genomic sequences, the study aims to uncover how these interactions contribute to the variability seen in cancer among individuals. Patients may benefit from insights that could lead to more personalized treatment approaches based on their unique genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cancer who are interested in understanding the genetic factors influencing their disease.
Not a fit: Patients with non-cancerous conditions or those who do not have a genetic predisposition to cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored cancer treatments based on individual genetic interactions.
How similar studies have performed: Previous research has shown promise in understanding genetic interactions in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Carter, Hannah Kathryn — University of California, San Diego
- Study coordinator: Carter, Hannah Kathryn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.