Understanding how inherited and tumor gene changes work together in cancer
Comprehensive identification of germline-somatic interactions
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-11146638
This project aims to discover how a person's inherited genes interact with new gene changes in their tumors to affect cancer development and treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11146638 on ClinicalTrials.gov |
What this research studies
We know that cancer is complex, with many different gene changes in tumors. This project looks at how the genes you are born with might influence these tumor changes, which could explain why cancers behave differently in different people. Researchers are developing computer tools to find these hidden connections by analyzing a very large collection of existing tumor gene data. This work will help us understand the forces that shape a tumor's genetic makeup, potentially leading to more personalized cancer care.
Who could benefit from this research
Good fit: This research is focused on understanding cancer genetics in adults, particularly those whose tumor genomic data is available for analysis.
Not a fit: Patients not affected by cancer or those whose genetic data is not part of large public datasets would not directly benefit from this specific computational analysis.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of individual cancer risk and help predict how patients might respond to different cancer treatments.
How similar studies have performed: While preliminary data suggests these gene interactions are important, this area of research is relatively new and has been challenging to study due to limited data, making this approach novel.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CARTER, HANNAH KATHRYN — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: CARTER, HANNAH KATHRYN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Biology, Cancer Genes, Cancer Treatment, Cancer-Promoting Gene, Cancers