Understanding how inherited and acquired genetic changes interact in cancer
Discover and Analyze Germline-Somatic Interactions in Cancer
This study is looking at how your inherited genes and changes in cancer cells work together to affect the way multiple myeloma behaves and responds to treatment, with the goal of finding more personalized treatment options just for you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arizona State University-Tempe Campus NIH-funded |
| Lab location | 1 site (Tempe, United States) |
| Project ID | NIH-10689887 on NIH RePORTER |
What this research studies
This research investigates the interactions between inherited genetic variants and acquired mutations in cancer cells, focusing on how these interactions influence tumor characteristics and treatment responses. By developing a new computational framework called Variants Interacting in Germline and Soma (VIGAS), the study aims to analyze multi-omics data to better understand these genetic relationships. Patients with multiple myeloma will be the primary focus, as the research seeks to uncover insights that could lead to more personalized treatment strategies based on individual genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple myeloma who are interested in understanding the genetic basis of their disease.
Not a fit: Patients with cancers other than multiple myeloma may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored cancer treatments by understanding the genetic factors that influence tumor behavior.
How similar studies have performed: Previous research has shown promise in understanding genetic interactions in cancer, but this specific approach using the VIGAS framework is relatively novel.
Where this research is happening
Tempe, United States
- Arizona State University-Tempe Campus — Tempe, United States (Active)
Researchers
- Principal investigator: Liu, Li — Arizona State University-Tempe Campus
- Study coordinator: Liu, Li
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.