Understanding how influenza viruses evolve and affect the immune system

NIAID Centers of Excellence for Influenza Research and Response

['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-11065382

This study is looking at what affects how the flu virus changes and spreads, and how our bodies fight it, so we can better understand how to protect ourselves and improve flu vaccines for everyone.

Quick facts

Phase['FUNDING_OTHER']
Study typeNih_funding
SexAll
SponsorUNIVERSITY OF PENNSYLVANIA (nih funded)
Locations1 site (PHILADELPHIA, UNITED STATES)
Trial IDNIH-11065382 on ClinicalTrials.gov

What this research studies

This research investigates the factors that influence the evolution and transmission of influenza viruses, as well as the immune response to these infections. By conducting cohort studies and sampling from both humans and animals, the research aims to identify the immunological factors that determine how well individuals respond to influenza vaccination and infection. The goal is to enhance our understanding of how to protect against influenza and improve vaccination strategies.

Who could benefit from this research

Good fit: Ideal candidates for participation include individuals who are at risk for influenza infection, such as those with compromised immune systems or chronic health conditions.

Not a fit: Patients who are not at risk for influenza or those who have already been vaccinated may not receive direct benefits from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective influenza vaccines and better strategies for preventing and treating influenza infections.

How similar studies have performed: Previous research has shown success in understanding influenza virus behavior and immune responses, indicating that this approach has potential for meaningful advancements.

Where this research is happening

PHILADELPHIA, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Conditions: Disease Outcome

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.