Understanding how influenza virus mRNAs are exported from the nucleus
Virulence Factor at the Interface of Viral and Cellular mRNA Nuclear Export
This study looks at how the flu virus uses a special protein to help its genetic material move within our cells, which could help the virus grow while making it harder for our bodies to fight it off.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10829809 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the influenza virus uses a specific protein, NS1, to facilitate the export of its mRNA from the nucleus to the cytoplasm. By examining the interaction between NS1 and cellular proteins involved in mRNA transport, the study aims to uncover how the virus manipulates cellular processes to enhance its own gene expression while inhibiting the host's antiviral responses. The research employs a variety of techniques, including genetics and advanced imaging methods, to explore these interactions in detail.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of or currently infected with influenza virus.
Not a fit: Patients with viral infections other than influenza may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antiviral therapies that target the viral mRNA export process, potentially improving treatment options for influenza infections.
How similar studies have performed: Previous research has shown success in targeting viral mechanisms for therapeutic development, indicating that this approach has potential for meaningful advancements.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Fontoura, Beatriz Ma — Ut Southwestern Medical Center
- Study coordinator: Fontoura, Beatriz Ma
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.