Understanding how influenza virus interacts with specific enzymes in the body
Interplay between influenza virus and S1P-metabolizing enzymes
This study is looking at how certain enzymes in our body that help with immune responses affect the flu virus, and it aims to find new ways to treat flu infections, which could help patients like you in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11124737 on NIH RePORTER |
What this research studies
This research investigates the relationship between the influenza virus and certain enzymes that metabolize sphingosine 1-phosphate (S1P), which play a role in the body's immune response. By studying how these enzymes affect viral replication and the host's defense mechanisms, the research aims to uncover new ways to combat influenza infections. The approach includes both laboratory experiments and animal models to explore how manipulating these enzymes can influence the severity of flu infections. Patients may benefit from insights that could lead to new antiviral treatments or strategies to enhance immune responses against the flu.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at high risk for severe influenza infections, such as the elderly or those with compromised immune systems.
Not a fit: Patients who are not affected by influenza or those who have already been vaccinated against the virus may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve patient outcomes during influenza infections.
How similar studies have performed: While the specific interplay between S1P-metabolizing enzymes and influenza is less explored, similar research has shown promise in understanding viral infections and host interactions.
Where this research is happening
Columbia, United States
- University of Missouri-Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Hahm, Bumsuk — University of Missouri-Columbia
- Study coordinator: Hahm, Bumsuk
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.