Understanding how influenza virus interacts with host proteins to enhance infection
RNA:protein interactions that dictate the success of influenza virus infection
This study is looking at how the flu virus copies itself and tricks our body's defenses, with the goal of finding new ways to help create better treatments for people who get sick with the flu.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11139201 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms by which the influenza virus replicates and interacts with host cellular factors. It focuses on specific RNA:protein interactions that influence the virus's ability to evade the immune response and promote its replication. By studying proteins like IFIT2 and the influenza nucleoprotein, the research aims to uncover new therapeutic targets that could improve antiviral strategies. Patients may benefit from insights that could lead to more effective treatments for influenza.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals at high risk for severe influenza, such as the elderly, young children, and those with compromised immune systems.
Not a fit: Patients who are not affected by influenza or those who have already received effective antiviral treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antiviral therapies that better control influenza infections.
How similar studies have performed: Previous research has shown success in understanding viral-host interactions, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Mehle, Andrew — University of Wisconsin-Madison
- Study coordinator: Mehle, Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.