Understanding how influenza virus affects critically ill young patients
Immunobiology of Influenza Virus-related Critical Illness in Young Hosts
This study is looking at how the immune system of young kids responds to the flu, especially those who get really sick, to find out why some children have worse symptoms than others and to help improve treatments in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10685616 on NIH RePORTER |
What this research studies
This research investigates the immune response to influenza virus infections in young patients, particularly those who become critically ill. It aims to understand how the body's immune system reacts to the virus and why some children experience severe symptoms while others do not. By studying the immune responses and genetic factors in these patients, the research seeks to identify potential markers that could predict severe illness and improve treatment strategies. The study involves collecting data from pediatric patients with influenza-related respiratory infections to analyze their immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 21 years old who have experienced severe influenza-related respiratory infections.
Not a fit: Patients who are not affected by influenza or who are older adults may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for severe influenza infections in children.
How similar studies have performed: Previous studies have shown success in understanding immune responses to influenza, indicating that this research builds on established findings.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Randolph, Adrienne G — Boston Children's Hospital
- Study coordinator: Randolph, Adrienne G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.