Understanding how influenza infection and vaccination protect children over time
Longitudinal dynamics of protection after influenza infection and vaccination
['FUNDING_R01'] · UNIVERSITY OF CHICAGO · NIH-10677791
This study is looking at how well kids' immune systems protect them from the flu after they get sick or vaccinated, and it aims to help us understand how long that protection lasts and how it varies among different children.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10677791 on ClinicalTrials.gov |
What this research studies
This research investigates how the immune response to influenza infection and vaccination protects children from future infections. By following a large group of children over several years, the study aims to understand the duration and effectiveness of this protection, taking into account factors like age, sex, and individual health history. Researchers will analyze data from the Nicaragua Pediatric Influenza Cohort Study, which has tracked thousands of children since 2011, to develop models that predict how well children are protected against different strains of the virus. This approach will help clarify the complex dynamics of immunity and inform future vaccination strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who have received influenza vaccinations or have experienced influenza infections.
Not a fit: Patients who are older than 11 years or those who have not been vaccinated against influenza may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccination strategies that enhance protection against influenza in children.
How similar studies have performed: Previous research has shown success in understanding immune responses to influenza, but this study aims to provide novel insights through longitudinal data collection.
Where this research is happening
CHICAGO, UNITED STATES
- UNIVERSITY OF CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COBEY, SARAH — UNIVERSITY OF CHICAGO
- Study coordinator: COBEY, SARAH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.