Understanding how influenza A viruses change and spread between people
Official title: Within and between host dynamics in influenza A virus antigenic evolution
Funded at Emory University · NIH-11061747 · Data updated 2026-11-12
This study is looking at how the flu virus changes over time to avoid our immune system, so we can better predict which strains might be around in the future and improve flu vaccines for everyone.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31AI179207-02 |
| Project ID | NIH-11061747 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are at risk of influenza infection, particularly those with pre-existing health conditions or weakened immune systems.
✕Less likely to help
Patients who are not at risk for influenza or those who have already been vaccinated against the current strains may not benefit from this research.
What this research studies
This research investigates the evolution of influenza A viruses and how they adapt to evade the immune responses of individuals. By studying genetically barcoded strains of the virus, the researchers aim to understand the dynamics of viral mutations both within individual hosts and during transmission between hosts. This knowledge could lead to improved vaccine design by anticipating which virus strains are likely to circulate in the upcoming flu seasons. The study will utilize advanced techniques like droplet digital PCR to analyze viral genetic changes.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines that better match circulating influenza strains, reducing the incidence of flu infections.
How similar studies have gone: Previous research has shown success in understanding viral evolution and its implications for vaccine development, indicating that this approach is promising.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Raghunathan, Vedhika — Emory University
- Study coordinator: Raghunathan, Vedhika
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.