Understanding how influenza A virus adapts to different hosts
Official title: Single cell heterogeneity of influenza A virus genetic diversity and host adaptation using drop-based microfluidics
Funded at Montana State University - Bozeman · NIH-10881984 · Data updated 2026-11-12
This study is looking at how the flu virus changes when it jumps from birds to humans, using a special method to see how different versions of the virus act in individual cells, which could help us find ways to stop future infections from animals to people.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Montana State University - Bozeman NIH-funded |
| Lab location | 1 site (Bozeman, United States) |
| Project start | July 5, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $186,519 |
| NIH project number | 5R21AI178432-02 |
| Project ID | NIH-10881984 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have been exposed to avian influenza viruses or are at risk of zoonotic infections.
✕Less likely to help
Patients who are not at risk of avian influenza or do not have a history of exposure to such viruses may not benefit from this research.
What this research studies
This research investigates how the influenza A virus (IAV) mutates to adapt to new hosts, particularly focusing on avian strains that can infect humans. Using a technique called drop-based microfluidics, the study analyzes viral genetic diversity at a single-cell level, which allows researchers to observe how different strains of the virus behave in various cell types. By examining these mutations and their effects on transmission and virulence, the research aims to provide insights into preventing future zoonotic infections. This approach could lead to a better understanding of how IAV evolves and spreads among different species.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and controlling influenza outbreaks in humans.
How similar studies have gone: Previous research has shown success in understanding viral mutations and host adaptation, making this approach promising for further exploration.
Where this research is happening
-
Montana State University - Bozeman
Bozeman, United States Active
Researchers
- Principal investigator: Loveday, Emma Kate — Montana State University - Bozeman
- Study coordinator: Loveday, Emma Kate
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.