Understanding how influenza A affects lung cells
The Cell Phenotyping and Mouse Core
['FUNDING_P01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10910883
This study is looking at how the flu virus can lead to pneumonia in mice to help us find better treatments for people with pneumonia caused by the flu.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10910883 on ClinicalTrials.gov |
What this research studies
This research focuses on creating a reliable model to study how influenza A virus causes pneumonia in mice. It involves generating and maintaining viral stocks, infecting experimental animals, and using advanced techniques to analyze immune cell responses in the lungs. The research employs tools like flow cytometry to identify and sort different types of immune cells, and RNA sequencing to understand how these cells respond at a genetic level. This work aims to provide insights that could lead to better treatments for pneumonia caused by influenza.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of severe influenza infections or those at high risk for pneumonia.
Not a fit: Patients who do not have a history of influenza infections or related respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients suffering from influenza-induced pneumonia.
How similar studies have performed: Previous research has successfully utilized similar animal models to study viral infections and their effects on lung health.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MISHARIN, ALEXANDER — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: MISHARIN, ALEXANDER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.