Understanding how inflammation works in severe infections
Molecular regulation of immunoproteasome assembly in inflammatory diseases
This project aims to understand how a specific part of our immune system, called the immunoproteasome, contributes to severe inflammation in patients with serious bacterial infections like those leading to ARDS.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11136911 on NIH RePORTER |
What this research studies
Severe bacterial infections can cause dangerous inflammation and extensive tissue damage, leading to organ failure and conditions like acute respiratory distress syndrome (ARDS), for which there are currently no specific treatments. This work focuses on the immunoproteasome, a key component of our immune system that plays a critical role in inflammatory responses. We are exploring how the immunoproteasome is put together and regulated at a molecular level. By uncovering these mechanisms, we hope to identify new ways to control harmful inflammation. This understanding could pave the way for developing new drug targets to treat devastating complications of severe infections.
Who could benefit from this research
Good fit: This foundational research is for future patients suffering from severe bacterial infections, particularly those who develop acute respiratory distress syndrome (ARDS).
Not a fit: Patients whose conditions are not related to severe bacterial infections or the specific inflammatory pathways being studied may not directly benefit from this particular research.
Why it matters
Potential benefit: If successful, this work could lead to new drug targets and treatments to reduce life-threatening inflammation and organ damage in patients with severe bacterial infections and ARDS.
How similar studies have performed: While preliminary studies have shown the immunoproteasome's involvement, the specific molecular regulation of its assembly and its role in ARDS are new areas being explored.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Zhao, Jing — Ohio State University
- Study coordinator: Zhao, Jing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.