Understanding how inflammation resolves after cardiac arrest
Resolution of inflammation after cardiac arrest
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11037921
This study is looking at how the immune system reacts after someone has a cardiac arrest outside of the hospital, with the hope of finding ways to reduce inflammation and help improve recovery and survival for those patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11037921 on ClinicalTrials.gov |
What this research studies
This research investigates the body's immune response following out-of-hospital cardiac arrest (OHCA), focusing on how inflammation can be resolved to limit neurological damage. By utilizing a biobank of blood samples from OHCA patients, the study employs advanced single-cell analysis to explore the roles of specific immune cells and cytokines in this process. The goal is to identify mechanisms that could potentially improve patient outcomes and survival rates after cardiac arrest. Through this work, researchers aim to uncover new therapeutic targets that could enhance recovery for affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an out-of-hospital cardiac arrest.
Not a fit: Patients who have not experienced cardiac arrest or those with pre-existing severe neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce brain injury and enhance recovery for patients who experience cardiac arrest.
How similar studies have performed: Previous research has shown promise in understanding immune responses in similar contexts, suggesting that this approach could yield valuable insights.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIM, EDY YONG — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: KIM, EDY YONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury