Understanding how inflammation resolves after cardiac arrest
Official title: Resolution of inflammation after cardiac arrest
Funded at Brigham and Women's Hospital · NIH-11037921 · Data updated 2026-11-12
This study is looking at how the immune system reacts after someone has a cardiac arrest outside of the hospital, with the hope of finding ways to reduce inflammation and help improve recovery and survival for those patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $690,435 |
| NIH project number | 5R01HL166487-03 |
| Project ID | NIH-11037921 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an out-of-hospital cardiac arrest.
✕Less likely to help
Patients who have not experienced cardiac arrest or those with pre-existing severe neurological conditions may not benefit from this research.
What this research studies
This research investigates the body's immune response following out-of-hospital cardiac arrest (OHCA), focusing on how inflammation can be resolved to limit neurological damage. By utilizing a biobank of blood samples from OHCA patients, the study employs advanced single-cell analysis to explore the roles of specific immune cells and cytokines in this process. The goal is to identify mechanisms that could potentially improve patient outcomes and survival rates after cardiac arrest. Through this work, researchers aim to uncover new therapeutic targets that could enhance recovery for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce brain injury and enhance recovery for patients who experience cardiac arrest.
How similar studies have gone: Previous research has shown promise in understanding immune responses in similar contexts, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Kim, Edy Yong — Brigham and Women's Hospital
- Study coordinator: Kim, Edy Yong
Related research
Other NIH-funded projects on the same topics.
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
-
Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
-
Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
-
Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
-
Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
-
Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.