Understanding how inflammation leaves a 'memory' in the pancreas
Defining the molecular determinants of inflammatory memory in the pancreas
This research explores how past inflammation in the pancreas can leave a lasting mark on cells, influencing how the organ responds to future challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11126658 on NIH RePORTER |
What this research studies
Our bodies constantly adapt to changes, and recent findings suggest that cells can remember past inflammation even after it has cleared. This 'inflammatory memory' means that the pancreas might respond differently to new issues based on its past experiences. We are using advanced models to see how pancreatic cells change at a molecular level after inflammation and how this memory might affect their ability to heal or even lead to problems like cancer. Our goal is to uncover the specific signals that create and maintain this memory.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the underlying causes of pancreatic inflammation, chronic pancreatitis, or pancreatic cancer.
Not a fit: Patients will not receive direct treatment or immediate health benefits from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent chronic pancreatitis and reduce the risk of pancreatic cancer by understanding and potentially erasing inflammatory memory.
How similar studies have performed: Recent studies, including our own preliminary work, have shown that cells can indeed retain an epigenetic memory of inflammation, suggesting this is a promising area of investigation.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Chandwani, Rohit — Weill Medical Coll of Cornell Univ
- Study coordinator: Chandwani, Rohit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.