Understanding how inflammation increases cancer risk in skin cells
Dissecting mechanisms of inflammation driven cancer susceptibility in epithelial barrier tissues
This study looks at how inflammation can change skin stem cells and their ability to heal, which might also increase the risk of cancer, helping us understand how to better prevent these issues for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10877776 on NIH RePORTER |
What this research studies
This research investigates how inflammation affects the regenerative capacity of skin epithelial stem cells (EpSCs) and their potential to lead to cancer. It focuses on the long-term effects of inflammatory exposure on these cells, particularly how it alters their genetic material and cellular behavior. By examining the molecular mechanisms involved, the research aims to uncover how inflammation can change the way these cells respond to stress and contribute to tumor formation. Patients may benefit from insights into how inflammation influences cancer risk, potentially leading to new prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with chronic inflammatory conditions affecting epithelial tissues, such as skin disorders.
Not a fit: Patients with non-epithelial cancers or those without a history of inflammatory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide critical insights into preventing inflammation-related cancers, particularly in skin tissues.
How similar studies have performed: Other research has shown promising results in understanding the link between inflammation and cancer, making this approach both relevant and potentially impactful.
Where this research is happening
New York, United States
- Sloan-Kettering Inst Can Research — New York, United States (Active)
Researchers
- Principal investigator: Cowley, Christopher — Sloan-Kettering Inst Can Research
- Study coordinator: Cowley, Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.