Understanding how inflammation in the brainstem affects breathing and heart control in epilepsy.
Investigating the role of brainstem neuroinflammation in cardiorespiratory control in a rat model of recurrent epilepsy
This study looks at how inflammation in a part of the brain affects breathing and heart rate in rats with epilepsy, hoping to find out why some people with epilepsy are at risk for sudden death, and to discover new ways to help keep them safe.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10879154 on NIH RePORTER |
What this research studies
This research investigates the impact of neuroinflammation in the brainstem on cardiorespiratory control in a rat model of epilepsy. It aims to uncover how repeated seizures may disrupt vital functions like breathing and heart rate, which are crucial for patients with epilepsy. By studying the role of specific brain cells involved in inflammation, the research seeks to identify mechanisms that could lead to increased risks of Sudden Unexpected Death in Epilepsy (SUDEP). The findings could provide insights into potential therapeutic targets for improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with refractory epilepsy who experience uncontrolled seizures despite treatment.
Not a fit: Patients with well-controlled epilepsy who do not experience seizures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage seizures and reduce the risk of life-threatening complications in epilepsy patients.
How similar studies have performed: While the specific approach of this research is novel, there is existing literature indicating that neuroinflammation plays a significant role in various neurological conditions, suggesting potential for success.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Osmani, Wasif a — Medical College of Wisconsin
- Study coordinator: Osmani, Wasif a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.