Understanding how inflammation can lead to preterm birth
A novel mechanism for inflammation-induced preterm birth via PR-A phosphorylation
This study is looking at how the hormone progesterone and inflammation in the uterus might lead to preterm birth, with the hope of finding new ways to help prevent it for expectant moms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11062391 on NIH RePORTER |
What this research studies
This research investigates the hormonal mechanisms that contribute to preterm birth, focusing on the role of the hormone progesterone and its receptors in the uterus. It aims to clarify how inflammation affects these hormonal signals, particularly through a specific phosphorylated form of the progesterone receptor. By studying myometrial cells, the research seeks to uncover how inflammation can disrupt the protective effects of progesterone, potentially leading to premature labor. The findings could provide insights into new therapeutic strategies to prevent preterm birth.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals at risk of preterm birth due to inflammation or infection.
Not a fit: Patients who are not pregnant or those with no history of preterm birth or related complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent preterm birth, improving outcomes for mothers and their babies.
How similar studies have performed: Previous research has shown promising results in understanding hormonal control of labor, but this specific mechanism linking inflammation and progesterone signaling is novel.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Mesiano, Sam Antonio — Case Western Reserve University
- Study coordinator: Mesiano, Sam Antonio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.