Understanding how inflammation affects the onset of PTSD
Investigation of the Central and Peripheral Inflammatory Mechanisms of PTSD Onset
This study is looking at how our genes and the environment around us can influence the chances of developing PTSD after a traumatic event, and it aims to find specific biological markers that could help identify who might be at risk, so we can better understand and prevent PTSD.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10707101 on NIH RePORTER |
What this research studies
This research investigates the complex relationship between genetic and environmental factors that contribute to the development of post-traumatic stress disorder (PTSD) after experiencing trauma. It focuses on identifying biomarkers, particularly DNA methylation patterns, that may indicate an individual's risk for PTSD based on their inflammatory responses. By examining how these biological changes affect brain regions involved in stress response, the study aims to uncover the mechanisms that lead to PTSD and potentially guide preventive interventions. Patients may be involved in providing biological samples and participating in assessments related to their trauma experiences.
Who could benefit from this research
Good fit: Ideal candidates for participation include adults aged 21 and older who have experienced traumatic events and may be at risk for developing PTSD.
Not a fit: Patients who have not experienced trauma or those who are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of biomarkers that help identify individuals at risk for PTSD, allowing for earlier intervention and tailored treatment strategies.
How similar studies have performed: Previous research has shown associations between inflammation and PTSD, suggesting that this approach has potential for meaningful insights, although the specific focus on DNA methylation as a biomarker is relatively novel.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Gill, Jessica Mary — Johns Hopkins University
- Study coordinator: Gill, Jessica Mary
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.