Understanding how inflammation affects pregnancy and fetal membrane health
Official title: Paracrine control of the maternal-fetal interface critical for pregnancy wellness
Funded at Case Western Reserve University · NIH-11094032 · Data updated 2026-11-12
This study is looking at why some babies are born too early and how things like inflammation and bleeding during pregnancy can cause problems, while also checking if a hormone called progesterone can help keep pregnancies healthy; it's for anyone interested in finding better ways to prevent preterm birth and protect both moms and their babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $560,036 |
| NIH project number | 5R01HD110512-03 |
| Project ID | NIH-11094032 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include pregnant individuals at risk of preterm birth due to inflammation or bleeding.
✕Less likely to help
Patients who are not pregnant or those with pregnancies that are not at risk for preterm birth may not benefit from this research.
What this research studies
This research investigates the mechanisms behind preterm birth and the weakening of fetal membranes, which can lead to serious complications for newborns. It focuses on how inflammation and bleeding during pregnancy contribute to these issues and explores the role of a hormone called progesterone in preventing damage. By using advanced laboratory techniques, the study aims to identify potential therapies that could help maintain pregnancy and improve outcomes for mothers and infants. The findings could lead to new strategies for preventing preterm birth and its associated risks.
Why it matters
Potential benefit: If successful, this research could significantly reduce the rates of preterm birth and improve neonatal health outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammation in pregnancy complications, suggesting that this approach could lead to effective interventions.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Moore, John J — Case Western Reserve University
- Study coordinator: Moore, John J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.