Understanding how inflammation affects organ function in children after blood and marrow transplants.
Inflammatory mechanisms responsible for the development of multiple organ dysfunction in pediatric patients following allogeneic blood and marrow transplantation (BMT).
This study is looking at how inflammation affects kids who have had a blood and marrow transplant, especially when it leads to serious breathing problems, and aims to find new ways to help these children recover better and avoid severe complications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10770412 on NIH RePORTER |
What this research studies
This research investigates the inflammatory mechanisms that lead to multiple organ dysfunction in pediatric patients following allogeneic blood and marrow transplantation (BMT). It focuses on understanding how complications such as respiratory failure and other treatment-related issues contribute to severe outcomes in these children. The study aims to identify novel strategies to reduce the incidence and severity of pulmonary dysfunction, particularly idiopathic pneumonia syndrome, which can be fatal. By exploring the role of specific inflammatory proteins, the research seeks to improve treatment responses and overall patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric patients aged 0-21 who are undergoing or have recently undergone allogeneic blood and marrow transplantation.
Not a fit: Patients who are not undergoing blood and marrow transplantation or those outside the pediatric age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies that reduce the risk of organ dysfunction and enhance recovery for children undergoing blood and marrow transplants.
How similar studies have performed: Previous research has shown success in understanding and treating complications related to blood and marrow transplants, particularly with therapies targeting inflammatory responses.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Cooke, Kenneth R — Johns Hopkins University
- Study coordinator: Cooke, Kenneth R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.