Understanding how inflammation affects nerve healing after injury
Official title: Regulation of Neuroinflammation after Peripheral Nerve Injury
Funded at Ball State University · NIH-10729778 · Data updated 2026-11-12
This study is looking at how the nervous and immune systems work together after nerve injuries, using rodent models to understand how inflammation can actually help nerves heal, which could lead to better recovery options for people with similar injuries.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ball State University NIH-funded |
| Lab location | 1 site (Muncie, United States) |
| Project start | May 17, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $447,000 |
| NIH project number | 1R15NS128837-01A1 |
| Project ID | NIH-10729778 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced peripheral nerve injuries, such as those from trauma or surgery.
✕Less likely to help
Patients with central nervous system injuries, such as spinal cord injuries or traumatic brain injuries, may not benefit from this research.
What this research studies
This research investigates the connection between the nervous and immune systems following peripheral nerve injuries. By using advanced techniques in molecular neuroscience and immunology, the study aims to characterize the immune response during the healing process in rodent models of sciatic nerve injury. The researchers will explore how inflammation can promote nerve regeneration in the peripheral nervous system, which differs from its inhibitory role in the central nervous system. This work could lead to new insights into improving recovery from nerve injuries.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients recovering from peripheral nerve injuries.
How similar studies have gone: Previous research has shown that understanding the immune response in nerve injuries can lead to significant advancements in treatment strategies, indicating that this approach has potential for success.
Where this research is happening
-
Ball State University
Muncie, United States Active
Researchers
- Principal investigator: Roossien, Douglas Howard — Ball State University
- Study coordinator: Roossien, Douglas Howard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.