Understanding how inflammation affects leukemia in older adults
Programmed necrosis regulation of leukemic transformation.
This study is looking at how long-term inflammation might affect the development of acute myelogenous leukemia in older adults, especially those with myelodysplastic syndrome, to find better ways to help patients at risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11046925 on NIH RePORTER |
What this research studies
This research investigates the relationship between chronic inflammation and the development of acute myelogenous leukemia (AML) in older adults, particularly those with myelodysplastic syndrome (MDS). It aims to explore how age-related inflammation may influence the progression of these blood disorders and the role of specific genetic mutations in this process. By analyzing data from electronic health records and conducting experiments in mouse models, the study seeks to uncover mechanisms that could lead to better early interventions for patients at risk. The ultimate goal is to improve treatment outcomes for older patients suffering from these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 65 and above, who have myelodysplastic syndrome or are at risk for acute myelogenous leukemia.
Not a fit: Patients under the age of 65 or those without myelodysplastic syndrome or related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and treatment strategies for older patients at risk of developing acute myelogenous leukemia.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammation in blood disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
Nashville, United States
- Veterans Health Administration — Nashville, United States (Active)
Researchers
- Principal investigator: Zinkel, Sandra S — Veterans Health Administration
- Study coordinator: Zinkel, Sandra S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.