Understanding how inflammation affects heart rhythm in obesity
Official title: Channelopathies of Inflammation
Funded at University of Utah · NIH-11063688 · Data updated 2026-11-12
This study is looking at how being overweight can cause inflammation that might lead to serious heart problems, and it’s testing a new treatment to help prevent these issues in people with obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | January 10, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $618,126 |
| NIH project number | 1R01HL177965-01 |
| Project ID | NIH-11063688 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are obese and at risk for heart rhythm disorders.
✕Less likely to help
Patients who are not obese or do not have a history of heart rhythm issues may not benefit from this research.
What this research studies
This research investigates the link between obesity, inflammation, and dangerous heart rhythms known as ventricular tachyarrhythmias (VT). It focuses on how excess fat in the body leads to the release of inflammatory substances like interleukin-6, which may disrupt normal heart function. The study aims to explore the underlying mechanisms of this process in laboratory settings and assess the effectiveness of a new anti-inflammatory treatment in animal models. By understanding these connections, the research seeks to pave the way for new therapies to prevent life-threatening heart conditions in obese patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of dangerous heart rhythms in obese individuals.
How similar studies have gone: Previous studies have shown promising results in targeting inflammatory pathways to improve heart health, suggesting potential success for this approach.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Aromolaran, Ademuyiwa — University of Utah
- Study coordinator: Aromolaran, Ademuyiwa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.