Understanding how inflammation affects healing in the intestines
Official title: Examining the role of epigenetic memory in intestinal regeneration
Funded at University of California, San Francisco · NIH-11042137 · Data updated 2026-11-12
This study is looking at how the cells in your gut that help with healing respond to inflammation and if they remember past inflammation, which could help us find better ways to support gut healing and manage related health issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $78,040 |
| NIH project number | 5F32DK137454-02 |
| Project ID | NIH-11042137 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have experienced intestinal inflammation or related conditions.
✕Less likely to help
Patients with non-inflammatory gastrointestinal conditions may not receive direct benefits from this research.
What this research studies
This research investigates how intestinal stem cells (ISCs) respond to inflammation and whether they retain a memory of past inflammatory events. By studying the effects of inflammation on ISCs, the research aims to uncover the mechanisms behind their regenerative capabilities. The approach involves analyzing epigenetic changes in ISCs after exposure to inflammatory stimuli, specifically looking at how these changes influence their ability to heal in future injuries. Patients may benefit from insights into how to enhance intestinal healing and manage related diseases.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for intestinal diseases by enhancing the body's natural healing processes.
How similar studies have gone: Previous research has shown that similar approaches in other epithelial tissues have successfully demonstrated the role of inflammatory memory in healing.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Viragova, Sara — University of California, San Francisco
- Study coordinator: Viragova, Sara
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.