Understanding how inflammation affects fat storage and metabolism in the liver
Inflammation and hepatic lipid metabolism
This study is looking at how inflammation affects fat storage in the liver, especially for people dealing with obesity and diabetes, by focusing on a protein called TBK1 and its interaction with another enzyme, to help us understand how these processes might lead to liver diseases like NASH.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10649651 on NIH RePORTER |
What this research studies
This research investigates the role of inflammation in liver fat metabolism, particularly in the context of obesity and diabetes. It focuses on a protein called TBK1, which is believed to influence how fat is stored and used in the liver. The study will explore how TBK1 interacts with another enzyme, ACSL1, during different metabolic states such as fasting and obesity. By understanding these mechanisms, the research aims to uncover how inflammation contributes to liver diseases like Nonalcoholic Steatotic Hepatitis (NASH).
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from obesity, diabetes, or related liver conditions such as fatty liver disease.
Not a fit: Patients without obesity, diabetes, or liver-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for liver diseases associated with obesity and diabetes.
How similar studies have performed: Previous research has shown that targeting metabolic pathways in the liver can lead to significant improvements in liver health, suggesting potential for success in this area as well.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Saltiel, Alan R. — University of California, San Diego
- Study coordinator: Saltiel, Alan R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.