Understanding how inflammation affects eye cell regeneration in zebrafish
Official title: Inflammatory Signaling and Regeneration in Zebrafish models of Retinal Degeneration
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-11038030 · Data updated 2026-11-12
This study looks at how inflammation affects the ability of zebrafish to heal their eyes after injury, which could help us understand new ways to treat inherited eye diseases in people.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $515,193 |
| NIH project number | 5R01EY034755-03 |
| Project ID | NIH-11038030 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with inherited retinal degenerations or those at risk of developing such conditions.
✕Less likely to help
Patients with retinal degeneration caused by non-genetic factors may not benefit from this research.
What this research studies
This research investigates the mechanisms behind retinal degeneration and regeneration using zebrafish models. It focuses on how chronic inflammation impacts the ability of zebrafish to regenerate photoreceptors after injury. By examining the role of specific signaling pathways, such as Notch and NF-kB, the study aims to uncover why certain zebrafish mutants fail to regenerate their retinal cells. The findings could provide insights into potential therapeutic approaches for inherited retinal diseases in humans.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance retinal regeneration and preserve vision in patients with inherited retinal degenerations.
How similar studies have gone: Previous research has shown promising results in understanding retinal regeneration in zebrafish, indicating that this approach has potential for success.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Perkins, Brian D — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Perkins, Brian D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.