Understanding how inflammation affects COVID-19 outcomes
Regulation of inflammatory gene expression during SARS2 infection
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-11006329
This study is looking at how the body's inflammation during a COVID-19 infection can help fight the virus but might also cause serious symptoms, and it aims to find new ways to manage this inflammation using already approved medications.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-11006329 on ClinicalTrials.gov |
What this research studies
This research investigates the role of inflammatory gene expression during SARS-CoV-2 infection, focusing on how the body's inflammatory response can both help clear the virus and potentially lead to severe symptoms. The study aims to explore the dynamics of gene activation and the impact of specific inhibitors on inflammatory responses. By examining the effects of Topoisomerase 1 inhibitors, which are already FDA approved, the research seeks to develop new therapeutic strategies to manage inflammation in COVID-19 patients. This could lead to improved treatment options for those suffering from severe symptoms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with COVID-19 who are experiencing severe symptoms related to inflammation.
Not a fit: Patients with mild COVID-19 symptoms or those who are not infected with the virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new therapies to reduce inflammation and improve outcomes for COVID-19 patients.
How similar studies have performed: Previous research has shown that targeting inflammatory responses can be effective in managing infections, suggesting potential success for this approach in COVID-19.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARAZZI, IVAN — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: MARAZZI, IVAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.