Understanding how inflammation affects blood vessel function
Mechanisms of vascular dysfunction in acute systemic inflammation
['FUNDING_OTHER'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-10873965
This study is looking into how sudden inflammation in the body affects blood vessels, especially during infections, to find new ways to improve blood flow and overall health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-10873965 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind blood vessel dysfunction caused by acute systemic inflammation, which can occur due to infections or other inflammatory triggers. It aims to identify the molecular pathways and protein interactions that lead to this dysfunction, as well as potential genomic signatures that could help in understanding the condition better. By exploring these factors, the research seeks to uncover new targets for improving vascular function and restoring balance in the body. The approach includes detailed biochemical assays and animal models to study these processes in a controlled environment.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients experiencing acute systemic inflammation, such as those with severe infections or critical illnesses.
Not a fit: Patients with chronic vascular conditions unrelated to acute inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve blood vessel function in patients suffering from acute systemic inflammation.
How similar studies have performed: While there have been studies targeting vascular pathways, the specific mechanisms of vascular dysfunction in acute systemic inflammation remain largely unexplored, making this research a novel endeavor.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STARK, RYAN J — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: STARK, RYAN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.