Understanding how inflammation affects blood cell function in sickle cell disease
Inflammation-associated Autophagy Dysfunction
This study is looking at how long-lasting inflammation affects blood cells in people with sickle cell disease, and it hopes to find new ways to help improve their health by understanding these changes better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Bloodworks NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11062958 on NIH RePORTER |
What this research studies
This research investigates the role of chronic inflammation, specifically driven by TNFα, in sickle cell disease (SCD) and how it disrupts the normal function of blood cells. The study focuses on understanding how inflammation leads to the accumulation of dysfunctional mitochondria in platelets and red blood cells, which may impair their ability to function properly. By exploring the mechanisms behind these changes, the research aims to identify potential therapeutic targets to improve patient outcomes. Patients may be involved in providing samples or data to help elucidate these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals diagnosed with sickle cell disease, particularly those experiencing complications related to inflammation.
Not a fit: Patients without sickle cell disease or those with unrelated blood disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve blood cell function and reduce complications in patients with sickle cell disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammation in blood disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- Bloodworks — Seattle, United States (Active)
Researchers
- Principal investigator: Davizon-Castillo, Pavel — Bloodworks
- Study coordinator: Davizon-Castillo, Pavel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.