Understanding how inflammation affects Alzheimer's disease
Transcriptional Control of Neuroinflammation in Alzheimer's Disease
This study is looking at how inflammation in the brain affects Alzheimer's disease, especially in people with early signs of memory problems, to find new ways to help prevent or treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11035075 on NIH RePORTER |
What this research studies
This research investigates the role of neuroinflammation in Alzheimer's disease (AD) by focusing on the amyloid plaques that are characteristic of the condition. It examines how certain immune cells and inflammatory cytokines contribute to the progression of AD, particularly in individuals with mild cognitive impairment. The study aims to identify new therapeutic strategies that could prevent or treat AD by targeting the inflammatory processes involved. By analyzing brain samples and blood from patients, researchers hope to uncover critical insights into the mechanisms driving neurodegeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or mild cognitive impairment.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting neuroinflammation as a therapeutic approach in Alzheimer's disease, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Zhou, Ming-Ming — Icahn School of Medicine at Mount Sinai
- Study coordinator: Zhou, Ming-Ming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.